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Reference List

Listed by Application Area

The following references are provided to demonstrate the broad range of application areas in which IgY antibodies are used. For the intended uses of IgY Lab System products, please refer to the specific product sheet or contact us to discuss.   

Therapeutic drugs

  1. Nilsson E, Larsson A, Olesen HV, Wejåker PE, Kollberg H. Good effect of IgY against Pseudomonas aeruginosa infections in cystic fibrosis patients. Pediatr Pulmonol. 2008 Aug 4. [Epub ahead of print]

  2.  Nilsson E, Kollberg H, Johannesson M, Wejåker P-E, Carlander D, Larsson A, More Than 10 Years’ Continuous Oral Treatment with Specific Immunoglobulin Y for the Prevention of Pseudomonas aeruginosa Infections: A Case Report. J Med Food; 10 (2):375–378 (2007)

  3.  Girard F, Batisson I, Martinez G, Breton C, Harel J, Fairbrother JM. (2006) Use of virulence factor-specific egg yolk-derived immunoglobulins as a promising alternative to antibiotics for prevention of attaching and effacing Escherichia coli infections. FEMS Immunol Med Microbiol. Apr;46(3):340-50.

  4.  Kollberg H, Carlander D, Olesen H, Wejåker PE, Johannesson M, Larsson A. Oral administration of specific yolk antibodies (IgY) may prevent Pseudomonas aeruginosa infections in patients with cystic fibrosis. A phase I feasibility study. Pediatric Pulmonolgy; 35:433-440 (2003)

  5.  Larsson A, Carlander D. (2003) Oral immunotherapy with yolk antibodies to prevent infections in humans and animals. Ups J Med Sci.;108(2):129-40.

  6.  Mine Y, Kovacs-Nolan J. (2002) Chicken egg yolk antibodies as therapeutics in enteric infectious disease: a review. J Med Food. Fall;5(3):159-69.

  7.  Shimamoto C, Tokioka S, Hirata I, Tani H, Ohishi H, Katsu K. (2002) Inhibition of Helicobacter pylori infection by orally administered yolk-derived anti-Helicobacter pylori antibody. Hepatogastroenterology. May-Jun;49(45):709-14.

  8.  Yokoyama H, Umeda K, Peralta RC, Hashi T, Icatlo FC Jr, Kuroki M, Ikemori Y, Kodama Y. (1998) Oral passive immunization against experimental salmonellosis in mice using chicken egg yolk antibodies specific for Salmonella enteritidis and S. typhimurium. Vaccine. Feb;16(4):388-93.


  1. Larsson A. and Lindahl T.L. (1993) Chicken anti-protein G for the detection of small amounts of protein G. Hybridoma, 12, 143-147.

  2.  Larsson A. and Lindahl T.L. (1993) Chicken antibodies: A tool to avoid interfer-ence in immunological assays. Avian immunology in progress, 62, 97-102.

  3.  Larsson A., Wejåker P.-E., Forsberg P.O. and Lindahl T.L.(1992) Chicken antibodies: A tool to avoid interference by complement activation in ELISA.J.Immunol.Methods,156,79-83.

  4.  Larsson A., Wejåker P.-E. and Sjöquist J.(1992) Chicken anti-protein A for the detection and capturing of protein A from Staphylococcus aureus in the presence or absence of mammalian IgG.Hybridoma, 11,239-243.

  5.  Larsson A. and Mellstedt H.(1992). Chicken antibodies: a tool to avoid interference by human anti-mouse antibodies in ELISA after in vivo treatment with murine monoclonal antibodies. Hybridoma 11,33-39.

  6.  Larsson A., Karlsson-Parra A. and Sjöquist J.(1991) Use of chicken antibodies in enzyme immunoassays to avoid interference by rheumatoid factors. Clinical Chemistry.37,411-414.

  7.  Larsson A. and Holmdahl R. (1990) A micro ELISA for determination of protein A-binding monoclonal antibodies. Hybridoma 9, 289-294.

  8.  Larsson A. and Sjöquist J. (1989) Binding of complement component C1q, C3, C4 and C5 to a model immune complex in ELISA. J. Immunol. Methods 119, 103-109.

  9.  Larsson A., Jonsson L. and Sjöquist J. (1988) Determination of circulating immune complexes by chicken anti-human C3 and anti-human C1q micro Elisa. J. Immunol. Methods 113, 93-99.

  10.  Zrein M., Weiss E. and M.H.V.van Regenmortel (1988) Detection of rheumatoid factors of different isotypes by ELISA using biotinylated avian antibodies.Immunol.Invest. 17:165-181.

Western blotting

  1. Jin M., Larsson A. and Nilsson B.O. (1991) A functionally active complement system is present in uterine secretion of the mouse prior to implantation. Am. J. Reprod. Immunol. 26, 53-57.

  2.  Larsson A. and Sjöquist J. (1989) Binding of complement component C5 to model immune complexes and the use of anti-C5 antibodies for determination of C5-containing circulating immune complexes. J. Clin. Lab. Immunol. 28, 5-9.


  1. Jin M., Larsson A. and Nilsson B.O. (1996) Monoclonal antibodies against unfertilized zona-free mouse oocytes: characterization and effects on fertilization. Molecular Reproduction and Development, 43, 47-54.

  2.  Olovsson M. and Larsson A. (1993) Biotin labelling of chicken antibodies and their subsequent use in ELISA and immunohistochemistry. Comparative Immu-nology, Microbi-ology and Infectious Diseases, 16, 145-152.

  3.  Hjortberg M., Jin M., Larsson A. and Nilsson B.O. (1991) Immunoglobulins and monoclonal anti-blastocyst antibodies in the mouse uterine secretion during the early pre-implantation period. J. Reprod. Immunol. 20, 277-287.

  4.  Holmdahl R., Jansson L., Larsson A. and Jonsson R. (1990) Arthritis in DBA/1 mice induced with passively trans-ferred type II collagen immune serum. Scand. J. Immunol. 31, 147-157.

Flow cytometry

  1. Larsson A., Nilsson B. and Eriksson M. (1999) Thrombocytopenia and platelet microvesicle formation caused by Legionella pneumophila infection. Thrombosis Research, 96, 391-397.

  2.  Eriksson M., Nelson D., Nordgren A. and Larsson A. (1998) Increased platelet microvesicles formation is associated with mortality in a porcine model of endotoxemia. Acta Anaesthesiologica Scandinavia, 42, 551-557.

  3.  Larsson A., Eriksson M., Lundahl T., Lundkvist K. and Lindahl T.L. (1998) Impaired platelet function in endotoxemic pigs analyzed by flow cytometry. Platelets, 9, 115-119.

  4.  Lundahl T.H., Lindahl T.L., Fagerberg I.H., Egberg N., Bunescu A. and Larsson A. (1996) Activated platelets and impaired platelet function in intensive care patients analyzed by flow cytometry. Blood Coagulation and Fibrinolysis, 7, 218-220.

  5.  Larsson A., Egberg N. and Lindahl T.L. (1994) Platelet activation and binding of complement components to platelets induced by immune complexes. Platelets. 5, 149-155.

  6.  Lindahl T. and Larsson A.(1993) C1q binding to platelets induced by monoclonal antibodies and immune complexes-A flow cytometric analysis.Platelets,4,73-77.

  7.  Lindahl T.L., Festin R. and Larsson A. (1992) Studies of fibrinogen binding to platelets by flow cytometry: An improved method for detection of platelet acti-vation. Thrombosis and Haemostasis, 68, 221-225.

Latex agglutination

  1. Larsson, A. and Sjöquist, J. (1989) Novel latex agglutination method with chicken anti-protein A for detection of Staphylococcus aureus infections. J. Clin. Microbiol. 27, 2856-2857.

  2.  Larsson A.and Sjöquist J. (1988) Chicken antibodies: A tool to avoid false positive results by rheumatoid factor in latex fixation tests.J.Immunol.Methods 108.205-208.

Livestock feed

  1. Chernysheva LV, Friendship RM, Gyles CL, Dewey CE. (2003) Field trial assessment of the efficacy of specific egg-yolk antibody product for control of postweaning E. coli diarrhea. Vet Ther. Fall;4(3):279-84.

  2.  Owusu-Asiedu A, Baidoot SK, Nyachoti CM, Marquardt RR. (2002) Response of early-weaned pigs to spray-dried porcine or animal plasma-based diets supplemented with egg-yolk antibodies against enterotoxigenic Escherichia coli. J Anim Sci. Nov;80(11):2895-903.

  3.  Yokoyama H, Hashi T, Umeda K, Icatlo FC Jr, Kuroki M, Ikemori Y, Kodama Y. (1997) Effect of oral egg antibody in experimental F18+ Escherichia coli infection in weaned pigs. J Vet Med Sci. Oct;59(10):917-21.

  4.  Zuniga A, Yokoyama H, Albicker-Rippinger P, Eggenberger E, Bertschinger HU. (1997) Reduced intestinal colonisation with F18-positive enterotoxigenic Escherichia coli in weaned pigs fed chicken egg antibody against the fimbriae. FEMS Immunol Med Microbiol. Jul;18(3):153-61.

  5.  Imberechts H, Deprez P, Van Driessche E, Pohl P. (1997) Chicken egg yolk antibodies against F18ab fimbriae of Escherichia coli inhibit shedding of F18 positive E. coli by experimentally infected pigs. Vet Microbiol. Mar;54(3-4):329-41.

Personal hygiene products

  1. Kruger C, Pearson SK, Kodama Y, Vacca Smith A, Bowen WH, Hammarstrom L. (2004) The effects of egg-derived antibodies to glucosyltransferases on dental caries in rats. Caries Res. Jan-Feb;38(1):9-14.

  2.  Zhou Z, Zhou R, Tang Z. (2003) [Effects of topical application of immunoglobulin yolk on mutans streptococci in dental plaque] Hua Xi Kou Qiang Yi Xue Za Zhi. Aug;21(4):295-7. Chinese.

  3.  Carlander D, Kollberg H, Larsson A. (2002) Retention of specific yolk IgY in the human oral cavity. BioDrugs. ;16(6):433-7.

  4.  Smith DJ, King WF, Godiska R. (2001) Passive transfer of immunoglobulin Y antibody to Streptococcus mutans glucan binding protein B can confer protection against experimental dental caries. Infect Immun. May;69(5):3135-42.

  5.  Hamada S, Horikoshi T, Minami T, Kawabata S, Hiraoka J, Fujiwara T, Ooshima T. (1991) Oral passive immunization against dental caries in rats by use of hen egg yolk antibodies specific for cell-associated glucosyltransferase of Streptococcus mutans. Infect Immun. Nov;59(11):4161-7.

Other applications

  1. Larsson A.and Sjöquist J.(1990) Chicken IgY: Utilizing the evolutionary difference. Comperative Immunology, Microbiology and Infectious Diseases 13, 199-201.

  2.  Lösch U.,Schranner I., Wanke R.and Jurgens L.(1986) The chicken egg, an antibody source.J.Vet.Med.33, 609-619.

  3.  Guss B., Eliasson M., Olsson A., Uhlén M., Frej A., Jörnvall H., Flock, J.and Lindberg, M. (1986) Structure of IgG-binding regions of streptococcal protein G. EMBO J. 5, 1567-1575.

  4.  Katz D., Lehrer S. and Kohn A. (1985) Use of chicken and rabbit antibodies in a solid phase protein A radioimmunoassay for virus detection.J.Virol.Methods 12:59-70.

  5.  Song C-S., Yu J-H., Bai D.H., Hester P.Y. and Kim K.-H.(1985) Antibodies to the a-subunit of insulin receptor from eggs of immunized hens.J.Immunol.135,3354-9.

  6.  Horton J.J., Holden C.A., Ward P.J., MacDonald D.M.and Sanderson A.R. (1984) Exploitation of phylogenetic distance in cell surface immune labeling: studies with beta2-microglobulin. J.Invest. Dermatol. 85:96-99.

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